Last edit: 26-Jul-26

Boolean Biotech
Brian Naughton's blog on hands-on biotech self-experimentation and computational/AI protein design

About

Boolean Biotech is Brian Naughton’s long-running personal blog documenting his own hands-on biotech experiments alongside computational and AI-driven protein design work. On the citizen-science side, he’s sequenced his own genome at home, run DNA sequencing on an Oxford Nanopore Flongle, tested his oral microbiome before and after taking probiotics, self-tracked blood glucose response to food with a continuous glucose monitor, and analyzed local water purity with a GeneQuant. On the computational side, he writes about AI-assisted antibody/protein binder design (including entries in Adaptyv’s public design competitions), comparisons of tools like AlphaFold, Boltz, and Chai-1, and bioinformatics workflow tooling.

The blog started in 2014 with a small side project: a self-contained JavaScript implementation of Needleman-Wunsch (pairwise global DNA sequence alignment), written after failing to find a simple existing one to just align two sequences on a webpage or in a Google Sheet.

http://blog.booleanbiotech.com/
Collection:  project
Start Date: 2014
Status: active
Type: Project
Location: United States
Tags: DNA, self-experimentation, sequencing, protein design, AI
Last edit: 26-Jul-26

Boolean Biotech
Brian Naughton's blog on hands-on biotech self-experimentation and computational/AI protein design

About

Boolean Biotech is Brian Naughton’s long-running personal blog documenting his own hands-on biotech experiments alongside computational and AI-driven protein design work. On the citizen-science side, he’s sequenced his own genome at home, run DNA sequencing on an Oxford Nanopore Flongle, tested his oral microbiome before and after taking probiotics, self-tracked blood glucose response to food with a continuous glucose monitor, and analyzed local water purity with a GeneQuant. On the computational side, he writes about AI-assisted antibody/protein binder design (including entries in Adaptyv’s public design competitions), comparisons of tools like AlphaFold, Boltz, and Chai-1, and bioinformatics workflow tooling.

The blog started in 2014 with a small side project: a self-contained JavaScript implementation of Needleman-Wunsch (pairwise global DNA sequence alignment), written after failing to find a simple existing one to just align two sequences on a webpage or in a Google Sheet.

http://blog.booleanbiotech.com/
Collection:  project
Start Date: 2014
Status: active
Type: Project
Location: United States
Tags: DNA, self-experimentation, sequencing, protein design, AI
http://blog.booleanbiotech.com/
Collection:  project
Start Date: 2014
Status: active
Type: Project
Location: United States
Tags: DNA, self-experimentation, sequencing, protein design, AI
Last edit: 26-Jul-26

Boolean Biotech
Brian Naughton's blog on hands-on biotech self-experimentation and computational/AI protein design

About

Boolean Biotech is Brian Naughton’s long-running personal blog documenting his own hands-on biotech experiments alongside computational and AI-driven protein design work. On the citizen-science side, he’s sequenced his own genome at home, run DNA sequencing on an Oxford Nanopore Flongle, tested his oral microbiome before and after taking probiotics, self-tracked blood glucose response to food with a continuous glucose monitor, and analyzed local water purity with a GeneQuant. On the computational side, he writes about AI-assisted antibody/protein binder design (including entries in Adaptyv’s public design competitions), comparisons of tools like AlphaFold, Boltz, and Chai-1, and bioinformatics workflow tooling.

The blog started in 2014 with a small side project: a self-contained JavaScript implementation of Needleman-Wunsch (pairwise global DNA sequence alignment), written after failing to find a simple existing one to just align two sequences on a webpage or in a Google Sheet.

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